May 15, 2007
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Corneal topography differs dramatically before and after epithelial debridement, study shows

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PARIS — Debriding the corneal epithelium before performing PRK can dramatically change the anterior corneal topography, according to a study presented here at the French Society of Ophthalmology annual meeting.

Damien Gatinel, MD, and colleagues used the Orbscan II (Bausch & Lomb) to measure corneal topography before and after epithelial debridement in 44 eyes of 25 patients scheduled for PRK. "After de-epithelialization, the topography map, which was performed on Bowman's layer, showed increased toricity, negative asphericity and irregularity," Dr. Gatinel said.

The observed effect, which the researchers dubbed EASE (epithelial anterior smoothing effect), may explain the discrepancy between anterior and posterior topographic elevations seen in eyes with early keratoconus, he said.

"It also questions the true interest of topography-guided or wavefront-guided PRK, since the surface that receives the laser ablation is significantly modified in comparison to the surface that was present during the [acquisition of the] wavefront or topography [maps]," Dr. Gatinel noted.