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Conversion formula suggested for comparing OCT measurements

Br J Ophthalmol. 2011;95(11):1552-1554.

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A study determined a conversion formula to compare time-domain and spectral-domain optical coherence tomography measurements, accounting for differing posterior boundary lines within the band of the outer retina.

Researchers reviewed central retinal thickness and retinal volume values measured by Stratus time-domain and Cirrus spectral-domain OCT (both Carl Zeiss Meditec) for 104 eyes with exudative age-related macular degeneration. A linear model using time-domain central retinal thickness as the fixed factor and spectral-domain central retinal thickness as the dependent variable enabled calculation of the conversion formula.

Stratus OCT positions the reference line at the surface of the most visible anterior line, corresponding to the junction of the inner and outer photoreceptor segments, while Cirrus OCT uses the third and most posterior boundary line.

"Besides different threshold algorithms and the pathology of neovascular AMD itself, differences in fixation might influence the variability of [central retinal thickness] and [retinal volume] values measured by Stratus or Cirrus OCT (resulting in smaller values for Cirrus OCT in some patients)," the study authors wrote.