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Contrast sensitivity improved with brimonidine therapy

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Contrast sensitivity scores improved in glaucoma patients treated with brimonidine in a small clinical study.

In the study at the University of Alabama at Birmingham, D.W. Evans and colleagues evaluated 16 newly diagnosed, previously untreated glaucoma patients, half of whom were randomized to brimonidine 0.2% and half to timolol 0.5%. Visual acuity, contrast sensitivity, IOP, blood pressure and heart rate were evaluated at baseline and at 3 months.

Brimonidine improved contrast sensitivity in the right eye at 6 and 12 cpd (p =.043, p = .017) and in the left eye at 3 and 12 cpd (p = .044, p = .046). Timolol decreased contrast sensitivity in the right eye at 18 cpd (p = .041). IOP reduction was similar in both groups. There was no change in any other measured parameter.

The study is published in the December issue of the British Journal of Ophthalmology.