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Combined PRK, cross-linking procedure may offer alternative treatment for keratoconus

Am J Ophthalmol. 2011;152(5):748-755.

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A procedure combining topography-guided PRK and corneal collagen cross-linking offered functional vision and stabilization of ecstatic disorder for patients with keratoconus, according to a study.

"Simultaneous photorefractive keratectomy followed by corneal collagen cross-linking seems to be a promising treatment alternative in our series of keratoconic patients," the study authors said.

The study included 31 eyes of 26 patients with progressive keratoconus. Mean follow-up time was 19.53 months; mean age was 29.3 years.

At final follow-up, mean preoperative spherical equivalent decreased from -2.3 D at baseline to -1.08 D (P < .001), logMAR uncorrected visual acuity decreased 0.46 (P < .001), logMAR best corrected visual acuity decreased 0.084 (P < .001), mean steep keratometry readings decreased by 2.35 D (P < .001), and the flat keratometry readings decreased by 1.18 D (P = .013).

The researchers noted that the study was limited by the absence of a control group, which would have facilitated a comparison between corneal cross-linking alone and topography-guided PRK followed by corneal cross-linking.