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CME reduces central retinal sensitivity, even after resolution
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Active cystoid macular edema causes a reduction in central retinal sensitivity that can persist even after the edema resolves, according to a study by researchers in Austria.
Christopher G. Kiss, MD, and colleagues at the Medical University of Vienna performed static threshold perimetry using the Micro Perimeter 1 (MP1, Nidek) on 27 eyes of 21 patients. All cases had chronic cystoid macular edema (CME) secondary to uveitis.
Investigators confirmed the presence of active CME in 19 eyes; eight eyes with a history of recurrent CME had normal foveal contours on optical coherence tomography, according to the study.
The researchers found no significant association between the mean differential sensitivity threshold and retinal thickness.
In eyes with CME, the mean differential threshold values within the central 2° of the stimulation pattern, as measured with the MP1, ranged from 5.8 dB to 9.5 dB. In eyes with a normal foveal contour but a history of CME, the mean threshold values ranged from 9.3 dB to 12.9 dB.
Mean retinal thickness ranged from 390 µm at 0° to 389 µm at 1° in eyes with active CME and from 199 µm to 211 µm in eyes with a normal fovea after CME had resolved, according to the study, published in the January issue of British Journal of Ophthalmology.