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Clinical features may help determine etiology of cytomegalovirus anterior uveitis
Am J Ophthalmol. 2008;146(6):883-889.e1
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Clinical features may aid in the determination of whether patients with presumed Fuchs' heterochromic iridocyclitis are positive for cytomegalovirus infection.
Researchers examined cytomegalovirus (CMV) anterior uveitis status with polymerase chain reaction in 103 eyes of 102 patients with presumed Posner-Schlossman syndrome or Fuchs' heterochromic iridocyclitis to study whether clinical features of verified CMV infection could be diagnostic.
Of the 67 eyes with Posner-Schlossman syndrome, 35 were positive for CMV. In the 36 eyes of the 35 patients with Fuchs' heterochromic iridocyclitis, 15 were positive for CMV. Eighteen of the 50 CMV-positive eyes had nodular endothelial lesions, and all Fuchs' heterochromic iridocyclitis eyes with positive results had reticulate deposits.
There was no clinical difference in eyes with Posner-Schlossman syndrome that were either positive or negative for CMV infection. However, patients with presumed Fuchs' heterochromic iridocyclitis that were positive for CMV were more likely to be older, male and have nodular endothelial lesions compared with patients with presumed Fuchs' heterochromic iridocyclitis who were CMV negative.