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Choroidal thickness reduced in patients with idiopathic macular hole
Am J Ophthalmol. 2011;151(1):112-117.
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Eyes with idiopathic macular hole and unaffected fellow eyes had significantly thinner choroids than eyes from a healthy control group, suggesting that choroidal thickness may play a role in the pathogenesis of idiopathic macular hole, a study found.
In the cross-sectional, prospective study, researchers recruited 22 patients who had a full-thickness unilateral idiopathic macular hole and 22 age- and sex-matched controls.
The groups showed a significant difference in choroidal thickness in the subfoveal area and 1,000 µm and 2,000 µm away from the fovea in the nasal and temporal regions.
While the control group had a mean subfoveal choroidal thickness of 245 µm, the idiopathic macular hole group measured 183.2 µm and the unaffected fellow eye group measured 196.6 µm.
A negative correlation was observed between subfoveal choroidal thickness and axial length among patients with macular hole (P = .01), fellow eyes (P < .01), as well as in controls (P = .01), according to the study.
In addition, the investigators found a negative correlation between choroidal thickness and age in control eyes (P = .02).