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Central corneal thickness, disc area negatively correlate in children with tilted disc

Br J Ophthalmol. 2008;92(11):1461-1466.

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Corneal biomechanical properties that are measured with the Reichert Ocular Response Analyzer do not vary with optic disc parameters or retinal nerve fiber layer thickness; however, in children with optic disc tilt, central corneal thickness and optic disc area are negatively correlated, a study has found.

In a cross-sectional study of 102 Singaporean children, central corneal thickness, corneal hysteresis and corneal resistance factor were not associated with retinal nerve fiber layer thickness or other optic nerve head measurements as assessed by Heidelberg Retinal Tomograph II. The schoolchildren ranged in age from 11 to 14 years, with a preponderance of children of Chinese descent (80%). They were enrolled in the Singapore Cohort Study of the Risk Factors of Myopia.

In the cohort of children studied, 44.1% of eyes had tilted discs.

"It is possible that corneal biomechanical behavior may indicate the structural integrity of the optic nerve head, thereby making the [corneal hysteresis] value an indicator of glaucoma susceptibility," according to the study authors.