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Case study: Long-term glucocorticoid use can lead to Cushing’s syndrome

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Prolonged and unsupervised use of glucocorticoid ocular drops may result in Cushing’s syndrome, according to a case study from the United Arab Emirates.

Bachar Afandi and colleagues in Abu Dhabi reported the case of a 33-year-old man with extensive ophthalmologic complaints and procedures who had used glucocorticoid ocular drops for an extended period of time. The patient was referred to an endocrinologist with the onset of type 2 diabetes.

Clinically the patient appeared cushingoid, with a buffalo hump, think skin, bruises and purple striae, the authors said. His blood pressure was 130/90 mm Hg.

After the patient discontinued use of the eye drops, his cushingoid features gradually faded and his blood pressure and serum glucose levels normalized.

The study is published in the November/December issue of American Association of Clinical Endocrinologists.