Case series: Sodium hyaluronate injection reversed hypotony

Intravitreal injection of sodium hyaluronate may be effective in reversing hypotony, according to a published case series. The authors noted that functional and structural findings in hypotonous eyes treated in this way may also be improved.

Gian Marco Tosi, MD, and colleagues at New York Presbyterian Hospital reported the effects of intraocular use of sodium hyaluronate 1.4% and 2.3% in five eyes. Three eyes underwent intravitreal injection of sodium hyaluronate 1.4% for the treatment of persistent hypotony after successful repair of retinal detachment. One eye with uveitis was also treated with injection of 1.4% sodium hyaluronate. One eye received injection with 2.3% sodium hyaluronate after successful repair of retinal detachment with removal of silicone oil. Follow-up ranged from 2 to 16 months.

IOP increased to at least 5 mm Hg in all eyes that underwent injection, with a range of 5 mm Hg to 14 mm Hg. IOP increased to 38 mm Hg on postoperative day 1 in the eye injected with the 2.3% solution and was 10 mm Hg at 3 months. All patients had improved vision.

The study is published in the November issue of the American Journal of Ophthalmology.