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Case report: Corticosteroid therapy improved melanoma-associated retinopathy

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Corticosteroid therapy is rarely beneficial in cases of melanoma-associated retinopathy, but a group in France recently reported a case in which the therapy resulted in improvement.

Caroline Jacobzone, MD, and colleagues in Brest, France, described the case of a 70-year-old woman who had sudden bilateral vision loss in 2001; she had had a first melanoma in 1985 and a second primary melanoma in 1994. Lymph node involvement led to surgery and chemotherapy in 2000.

The patient presented with bilateral posterior uveitis with hyalitis and progressive destruction of retinal pigment. Electrophysiologic data confirmed the diagnosis of melanoma-associated retinopathy (MAR). The symptoms improved after systemic corticosteroid therapy, with no relapse after tapering the dose, despite worsening of the melanoma, the authors reported.

Corticosteroid therapy is rarely beneficial in MAR, the authors said. “Our case of MAR is noteworthy because it involved a woman, was associated with an uveitis, and improved with corticosteroid therapy,” the authors reported in the October issue of Archives of Dermatology.