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Carboplatin can lead to blinding ocular toxicity
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HIROSHIMA, Japan — Intracarotid injection of carboplatin for treatment of a brain tumor can lead to blinding ocular toxicity, warn the authors of a case report here.
Wataru Watanabe and colleagues reported the case of a 58-year-old man who received an intracarotid injection of carboplatin as part of the treatment regimen for recurrent glioblastomas in his left temporal lobe. He complained of pain and visual disturbance in the ipsilateral eye 30 hours after the injection. Various ocular symptoms and findings caused by carboplatin toxicity were seen, according to the report.
The patient was treated with intravenous administration of corticosteroids and glycerin for 6 days after the injection. Although the intraocular pressure elevation caused by secondary acute angle-closure glaucoma decreased, and ocular pain diminished, inexorable papilledema and exudative retinal detachment continued for 3 weeks. After an additional 6 weeks, diffuse chorioretinal atrophy with optic atrophy occurred, and the vision in the patient's left eye was lost.
The report is published in Graefe's Archive for Clinical and Experimental Ophthalmology.