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Capsular bending effect similar with acrylic, silicone IOLs in animal study
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No substantial difference in posterior capsular opacification was found between IOLs with sharp posterior optic edges, regardless of the IOL material, in an animal study. These results confirm that the capsular bending effect resulting from a sharp posterior IOL optic edge is “the main factor in preventing PCO,” the study authors said.
Okihiro Nishi, MD, and colleagues at the Nishi Eye Hospital in Tokyo compared the preventive effect of four types of design- and material-matched IOLs on PCO in rabbit eyes. After phacoemulsification, one of two matched IOLs in three groups was implanted in one eye and the other IOL in the contralateral eye of four to six rabbits. Three weeks postoperatively, the amount of PCO in each eye was evaluated histologically and with posterior view.
Capsular bending was similar between the sharp-edged acrylic Sensar IOL and the sharp-edged silicone Clariflex IOL, both from Advanced Medical Optics. Capsular bending was also similar between the Sensar and another sharp-edged acrylic IOL, the Alcon AcrySof. No significant differences between the IOL types in the amount of PCO were found.
The capsular bend effect was slightly better and the PCO amount slightly less with the sharp-edged silicone IOL than with a round-edged silicone IOL, the AMO PhacoFlex II.
The study is published in the October issue of Journal of Cataract & Refractive Surgery.