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Canaloplasty may be safe, effective for reducing IOP in open-angle glaucoma

J Glaucoma. 2011; 20(5): 298-302.

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In patients with open-angle glaucoma, canaloplasty may be effective and safe for decreasing IOP, a study suggested.

Thirty-two white patients with open-angle glaucoma and uncontrolled IOP underwent primary canaloplasty in a single-center prospective study looking at the safety and effectiveness of the procedure for this indication.

Mean IOP dropped from 27.3 mm Hg preoperatively to 12.8 mm Hg in 25 eyes at the 12-month follow-up. Of the eyes, 93.8% reached a target pressure of 21 mm Hg or less, 84.4% of eyes achieved 18 mm Hg or less, and 74.9% of eyes achieved 16 mm Hg or less, all with no medications. No major complications were noted postoperatively.

This is one of the few studies to report on the outcome and safety of canaloplasty for open-angle glaucoma, which incorporates an ab externo approach to stretch the inner wall of Schlemm’s canal, rather than the more traditional trabeculectomy, which incorporates an ab interno approach, the study authors said.

“A great advantage of canaloplasty over trabeculectomy is the potential of fewer postoperative complications as canaloplasty is not only a nonpenetrating but also bleb-independent procedure,” the study authors said.