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Brinzolamide, apraclonidine both prevent IOP spikes after posterior capsulotomy

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Prophylactically treating patients using brinzolamide 1% or apraclonidine 0.5% before Nd:YAG laser posterior capsulotomy prevented IOP spikes after the treatment, a Turkish study found.

Mustafa Ünal, MD, and colleagues at Akdeniz University prospectively compared the two drugs in 115 patients treated with the YAG for posterior capsule opacification. All doses were applied 1 hour before surgery.

From 1 hour to 7 days after laser application, both groups had similar mean IOP changes from baseline. Among 57 eyes in the brinzolamide group, IOP elevations of 5 mm Hg or more occurred in seven eyes (12.2%) and of 10 mm Hg or more in two eyes (3.5%). Among 58 eyes in the apraclonidine group, IOP increased by 5 mm Hg or more in six eyes (10.3%) and by 10 mm Hg or more in one eye (1.7%), according to the study.

No eyes experienced IOP elevations greater than 20 mm Hg, the authors noted.

The study is published in the September issue of the Journal of Cataract & Refractive Surgery.