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Botulinum toxin A resolves symptoms of superior limbic keratoconjunctivitis in study

Cornea. 2009;28(7):752-758.

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Injections of botulinum toxin A used as rescue therapy for patients with superior limbic keratoconjunctivitis resolved symptoms within 1 week, and the effect was maintained for an average of 4 months after treatment, according to a study.

In a cohort of eight patients treated with a large-diameter contact lens, three patients had complete resolution lasting 1 month or more after a week of wearing the lens, according to the study. However, two patients discontinued use of the contact lens on day 3 of the protocol after developing significant superficial punctate keratopathy.

In five patients with a recurrence of keratoconjunctivitis, botulinum toxin A was injected into the pretarsal orbicularis muscle.

"Clinical symptoms were improved within 1 week and vital staining within 2 weeks," according to the study. "Maintenance of effect was a mean of 4 months (range from 2 to 6 months)."