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Anti-inflammatory therapy effective for KCS, lit review finds
Cyclosporine A can help improve the signs and symptoms of keratoconjunctivitis sicca and is safe for long-term use, according to a review of the published evidence.
Stephen C. Pflugfelder, MD, of the Baylor College of Medicine in Houston, analyzed published studies that evaluated inflammation in the pathogenesis of dry eye and clinical trials of anti-inflammatory therapies for dry eye. Dr. Pflugfelder said there is increasing evidence that decreased tear secretion, decreased tear turnover and desiccation promote inflammation on the ocular surface. Clinical improvement of keratoconjunctivitis sicca has been observed after therapy with anti-inflammatory agents including corticosteroids, cyclosporine and doxycycline, he said.
The analysis is published in the February issue of American Journal of Ophthalmology.