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Anterior scleral thickness correlated with CCT in patients with normal-tension glaucoma
J Glaucoma. 2011;20(2):95-99.
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Researchers observed a correlation between central corneal thickness and anterior scleral thickness in patients with normal-tension glaucoma but not in patients with primary open-angle glaucoma, a study said.
Of the 108 Korean participants in the prospective study, 36 had NTG, 35 had POAG and 37 did not have glaucoma and served as controls. CCT and anterior scleral thickness (AST) were measured with anterior segment optical coherence tomography (Visante, Carl Zeiss Meditec).
CCT was thinner in the NTG group (514.81 ± 25.03 µm) compared with the POAG group (534.43 ± 34.79 µm; P = .023) and the control group (536.70 ± 32.11 µm; P = .009).
AST was also thinner in the NTG group (738.53 ± 53.63 µm) compared with the POAG group (771.86 ± 53.75 µm; P = .032) and the control group (783.62 ± 57.03 µm; P = .002).
Researchers observed a correlation between CCT and AST in the NTG patients only. However, further research is "needed to determine whether the relationship between CCT and AST could be applicable to the biomechanic properties of the optic nerve head" in these patients, the study said.
"Unless the thickness of the lamina cribrosa and peripapillary sclera can be measured in vivo, and its association with AST and CCT is adequately defined, the clinical impact of the present findings is unclear," the authors said.