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Amniotic membrane with trab may be safer than mitomycin, though less effective
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ELAZIG, Turkey — Amniotic membrane transplantation is less effective than mitomycin C for suppressing wound healing after trabeculectomy, according to a study in rabbits. However, considering the potential adverse effects of antimetabolite use, membrane transplantation may be a safer alternative, the study authors suggest.
Tamer Demir, MD, and colleagues compared the modulation of wound healing achieved in two groups of 10 rabbit eyes in which trabeculectomies were performed. One group was treated with mitomycin-soaked sponges, and in the other amniotic membrane was transplanted around the scleral flap.
A third group served as control. The mean number of fibroblast and macrophage cells significantly decreased in the mitomycin group compared to control eyes (P < .0001). The amniotic membrane group also had lower fibroblast (P < .0001) and macrophage (P < .01) cell counts than the control group. However, the difference between the two treatment groups was only statistically significant for fibroblast cell counts (P < .0001).
The study is published in Ophthalmologica.