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Age, IOP fluctuation associated with visual field loss over time: AGIS

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Patients in a large clinical study had a 30% increase in the odds of progression of visual field damage for every 5-year increase in age and 1 mm Hg fluctuation in IOP, according to a recent study. The higher risk with IOP fluctuation was found to be consistent regardless of history of cataract surgery, the study authors said.

Kouros Nouri-Mahdavi, MD, and colleagues studied data on 509 eyes of 401 patients who were included in the Advanced Glaucoma Intervention Study (AGIS).

Patients had at mean follow-up time of 7.4 years. Mean baseline AGIS visual field score was 7.7, according to the study authors.

Progressive visual field loss, which was detected in 151 of the 509 eyes (30%), was significantly associated with older age at the time of the initial glaucoma intervention (P = .0012), with greater IOP fluctuations (P = .0013), with greater numbers of glaucoma interventions (P = .01) and with longer duration of follow-up (P = .02), according to the study.

After regression analyses, only IOP fluctuation was consistently associated with progressive visual field loss in eyes both with and without a history of cataract surgery.

The study is published in Ophthalmology.