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Age a factor in iris color changes from latanoprost use, study finds

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Age appears to be an important risk factor influencing changes in iris pigmentation resulting from latanoprost use, a prospective study suggests.

Esther Arranz-Marquez, MD, PhD, and colleague Miguel A. Teus, MD, PhD, compared the incidence of iris color change between two groups of 36 patients with primary open-angle glaucoma. The first group included patients younger than 60 years; the second group included patients older than 75 years.

The researchers obtained photographs of both irides of each patient before beginning unilateral treatment with Xalatan (latanoprost, Pfizer) and again at 6 months follow-up. They found that eight patients (22.22%) in the first group and 28 patients (77.78%) in the second group developed an increase in iris pigmentation (P = .0001), according to the study.

Both groups were matched in basal iris colors at baseline, the authors noted.

The study is published in the July issue of American Journal of Ophthalmology.