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Adrenomedullin levels higher in patients with diabetic retinopathy
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FUKUOKA, Japan — Patients with diabetic retinopathy showed an increase in vitreous levels of adrenomedullin compared to patients with macular holes, a study here found. Researchers suggested the increased level of adrenomedullin may be related to diabetic retinopathy.
Adrenomedullin is a peptide with various physiological actions, including vasodilation, regulation of growth and regulation of glucose and insulin.
Shinji Ito and others here with Kyushu University measured the vitreous adrenomedullin levels in patients with diabetes to determine its potential involvement in the pathogenesis of diabetic retinopathy. Thirteen of the patients had diabetic retinopathy, and 15 had macular holes. Patients with diabetic retinopathy had significantly higher adrenomedullin levels in their vitreous fluid than patients with macular holes.
The study is published in the January issue of Ophthalmologica.