This article is more than 5 years old. Information may no longer be current.
Adjunctive cyclosporine with filtering surgery had no positive effect in rabbit study
Click Here to Manage Email Alerts
Use of cyclosporine during or after trabeculectomy in rabbits was associated with no decrease in IOP or prolongation of bleb survival compared to untreated controls, according to a recent publication. In fact, postoperative topical treatment with cyclosporine mitigated the beneficial effects of mitomycin C on bleb survival, the study authors said.
Frank A. Lattanzio Jr., PhD, and colleagues applied intraoperative or postoperative topical cyclosporine to rabbits undergoing glaucoma filtration surgery with drainage tubes. Results were compared with rabbits treated intraoperatively with mitomycin and untreated controls.
In the untreated control group, blebs remained elevated for a mean 15.1 days, after intraoperative cyclosporine a mean 12.2 days, and after intraoperative mitomycin a mean 27.5 days. When topical treatment with cyclosporine followed intraoperative mitomycin, bleb survival significantly decreased to an average of 19.2 days. IOP remained significantly reduced in the mitomycin-treated group longer than in either the control or the cyclosporine group.
The study is published in the December issue of Journal of Glaucoma.