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54% of allogeneic stem cell transplantation patients developed ocular graft-versus-host disease
Cornea. 2010;29(7):758-763.
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Approximately 54% of patients who received allogeneic stem cell transplantation experienced ocular graft-versus-host disease, with dry eye and conjunctivitis the most common complications, a study found.
The study also found that blepharitis and uveitis were not as commonly reported.
"Ocular [graft-versus-host disease] develops in a substantial part of patients after [allogeneic stem cell transplantation] and decreases the activities of daily living," the study authors said.
The prospective study examined 101 subjects who had allogeneic stem cell transplantation between 2004 and 2007. Follow-up was 3 months, with ocular complaints followed up at 12 and 24 months.
At 3 months, the study found a marked association between acute systemic graft-versus-host disease, including the mouth and skin, and ocular graft-versus-host disease.
It also found that 24 of 54 patients (44%) reported that ocular issues affected activities of daily living. In addition, 16 patients (30%) had temporary visual acuity loss exceeding more than two Snellen lines. One patient had permanent unilateral vision loss from ischemic vasculopathy, the authors said.
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