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CNTF可缩小地图状萎缩

Issue: December 2008

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2期研究的期中结果显示，睫状节神经细胞营养因子(ciliary neurotrophic factor)可有效缩小干性老年黄斑变性患者的地图状萎缩(geographic atrophy)。

“黄斑变性治疗中新的法宝是终止地图状萎缩的进展，我们认识到这是导致萎缩性AMD患者视力严重下降最常见的原因，”医学博士、工商管理硕士卡门·A.·普里菲托(Carmen A. Puliafito)在美国眼科学会年会前的“视网膜亚专业日”上说：“CNTF是一种可促进对视网膜细胞进行挽救的强大细胞因子。”

他说，27名用高剂量CNTF治疗的患者，地图状萎缩的面积平均缩小了1.3 mm²。高剂量和低剂量治疗组的黄斑面积分别平均增加了0.5 mm²和0.3 mm²。

普里菲托博士说：“一项2期研究的期中结果显示出缩小地图状萎缩面积、增加OCT黄斑面积这些有前景的生物学趋势。”