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Neuro-Ophthalmology News
FDA approves Ultomiris for neuromyelitis optica spectrum disorder
The FDA approved Ultomiris for the treatment of adults with anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder, according to a press release from Alexion.
Physical activity may have neuroprotective effects on the retina
Increased physical activity may be associated with slower rates of macular ganglion cell-inner plexiform layer thinning, according to a study published in Investigative Ophthalmology & Visual Science.
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Presence of cytokines linked to NMOSD activity
Presence of cytokine proteins in those with neuromyelitis optica spectrum disorder was linked to disease activity, which was lessened after treatment with inebilizumab, according to a presentation from ECTRIMS 2023.
FDA requests modifications to safety program for AZ’s Ultomiris
The FDA has issued a complete response letter to AstraZeneca for its supplemental biologics license application of Ultomiris to treat adults with neuromyelitis optica spectrum disorder who are anti-aquaporin-4 antibody positive.
VIDEO: Inebilizumab reduces plasma cell signature, B-cell intrusion in NMOSD attacks
Treatment with inebilizumab was effective in reducing two telltale signs of an attack of neuromyelitis optica spectrum disorder, Bruce A. Cree, MD, PhD, MAS, said in this Healio video.
Lumevoq demonstrates sustained improvement of BCVA up to 5 years in LHON
BOSTON — Results from the long-term RESTORE study show patients with Leber hereditary optic neuropathy with ND4 mutation who were treated with Lumevoq had sustained improvement of best-corrected visual acuity in both eyes.
Uplizna reduced subclinical optic nerve lesions in neuromyelitis optica spectrum disorder
Horizon Therapeutics recently announced new MRI imaging data from a phase 3 clinical trial, which demonstrated that Uplizna reduced formation of asymptomatic optic nerve lesions in patients with neuromyelitis optica spectrum disorder.
Quantitative pupillometry may be effective assessment tool in emergency setting
Quantitative pupillometry may be a reliable method of assessing clinically intoxicated patients in EDs, per a study published in the Journal of the American College of Emergency Physicians Open.
Acute exposure to negative pressure did not reverse spaceflight-induced ocular changes
An OCT study on spaceflight crew members found ocular morphology alterations potentially related to weightlessness and chronic headward fluid shift were not reversed by short-duration lower body negative pressure countermeasures.
Anxiety, depression worse among older men with vision impairment
Self-reported symptoms of anxiety and depression were higher among men aged 50 years and older with vision impairment, compared with those with normal vision, study findings showed in International Health.
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