Epilepsy News

Higher tissue 2-hydroxyglutarate concentration appeared to increase risk for preoperative seizures in isocitrate dehydrogenase 1/2 mutant tumors, according to study results published in Neurology.

Amzell BV, a specialty pharmaceutical development company, announced it has a special protocol assessment agreement with the FDA for a phase 3 trial of its injectable infantile epileptic disease therapy.

Patients who received enzyme-inducing antiseizure medications had increased risk for incident cardiovascular disease, according to results of a cohort study published in JAMA Neurology.

Levetiracetam was well tolerated and appeared to improve performance on spatial memory and executive function tasks among patients with Alzheimer’s disease, according to results of a randomized clinical trial in JAMA Neurology.

The FDA has approved an expanded indication for Briviact CV tablets, oral solution and injection, for treating partial-onset seizures among children as young as 1 month.

Cannabidiol transdermal gel improved outcomes among children with developmental and epileptic encephalopathies, according to results of a nonrandomized controlled trial published in JAMA Network Open.

Individuals with familial cerebral cavernous malformation had a high incidence rate of seizures, according to study findings published in Neurology.

Findings published recently in Journal of Medical Economics demonstrated that patients with focal seizures who began first adjunctive therapy with eslicarbazepine acetate vs. brivaracetam had considerably larger reductions in medical costs.

Patients with focal seizures who initiated first adjunctive therapy with eslicarbazepine acetate vs. brivaracetam had significantly larger reductions in medical charges, as well as in prescription charges unrelated to anti-seizure drugs.

Decreased levels of plasma amyloid beta 42 at midlife, but not late life, correlated with an increased risk for dementia and a “marginally higher” risk for mild cognitive impairment, according to findings published in Neurology.