Transplantation News

The Conferences Committee for the 47th ANNA National Symposium, the ANNA Research Committee, and the ANNA Specialty Practice Leaders have accepted the following abstract submitted for the 2016 National Symposium in Louisville, KY.

People who had cancer before receiving an organ transplant were more likely to die of any cause, die of cancer, or develop a new cancer than organ recipients who did not previously have cancer, a new paper has found. However, the increased risk is less than that reported in some previous studies.

New clinical trial results show that transplanted human islets prevent hypoglycemic events and provide excellent glycemic control for patients with Type 1 diabetes with severe hypoglycemia. The results of the multi-center, single arm, phase III study were published in Diabetes Care April 18. The research was funded by National Institute of Health (NIH) grants through the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute for Diabetes and Digestive and Kidney Disease (NIDDK).

In animal models of transplantation, females show increased tolerance to ischemia-reperfusion injury (IRI), compared to males, but it’s unclear whether sex disparities extend to human kidney transplantations, according to an analysis of patient data published online in the Journal of Clinical Investigation from researchers at the Perelman School of Medicine at the University of Pennsylvania.

“If you do not donate then many people will die.”

Scientists have developed an immune-suppressing drug regimen that, when used in combination with genetically-modified pig organs, has enabled the longest-to-date survival of a heart transplant from a pig to a primate (baboon). Their study, published online in Nature Communications, could lead to expanded use of xenotransplantation.

More than half of kidney transplant recipients will visit an emergency department in the first two years after transplantation, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).

Genome-wide molecular profiling of kidney biopsies may be a key to catching organ rejection before it’s too late, according to a study led by scientists at The Scripps Research Institute (TSRI). The research demonstrates that acute and chronic kidney rejection—currently believed to be separate diseases—are actually different parts of the arc of the same immune rejection process.

Many kidney transplant recipients might benefit from a lower-than-standard dose of calcineurin inhibitors (CNI), according to research conducted by the Perelman School of Medicine at the University of Pennsylvania, in partnership with ECRI Institute. Their findings are detailed in a study published this week in the American Journal of Transplantation, with additional research included online in an extended Agency for Healthcare Research and Quality (AHRQ) report.

Despite immunologic challenges, transplanting across human leukocyte antigen (HLA) antibodies may be a significantly better long-term survival option than waiting years for a compatible donor, according to a new Johns Hopkins University School of Medicine study of more than 1,000 incompatible kidney transplants.