Fluid Management News

DALLAS — After an infant developed cyanosis and bradycardia during hemodialysis, researchers concluded that currently available dialysis machines may not be well-suited for small children and may result in unintended adverse effects, according to a case study presented at the Annual Dialysis Conference.

Fresenius Medical Care North America’s Renal Therapies Group announced it has received breakthrough device designation from the FDA for its computer-assisted ultrafiltration control software.

SAN DIEGO — In this exclusive video from ASN Kidney Week 2018, Ian Sabir, June Zhao, MD, PhD and Ayman Al-Shurbaji, MD, PhD, discuss a phase III study that compared 5 g and 10 g of Lokelma (sodium zirconium cyclosilicate, AstraZeneca) with placebo for the treatment of hyperkalemia.

Investigators found oxycodone is removed during hemodialysis. However, not enough is removed to require additional dosing in patients with ESRD. According to findings published in Nephrology Dialysis Transplantation, the pharmacokinetics of oxycodone and the absence of unconjugated active metabolites demonstrate oxycodone can be used at the usual dosage.

When presented together, malnutrition, fluid overload and resulting inflammation can have a detrimental effect on survival among patients with ESRD, according to a study by researchers from the Netherlands and the United States. However, malnutrition as a singular risk factor “was not associated with increased mortality risk,” the study authors noted. “The highest mortality risk was observed in patients where all three risk factors were present.”

Among patients with moderate CKD on a tightly controlled dietary intake, 24-hour urine phosphorus was highly variable and unrelated to dietary phosphorus intake or absorption and was inversely related to phosphorus retention, according to research that appears in the Clinical Journal of the American Society of Nephrology.

Among patients with atrial fibrillation and dialysis-dependent end-stage renal disease, apixaban was associated with lower risk for bleeding than warfarin, researchers reported.

Infant boys with hydronephrosis who received newborn circumcision had a significantly decreased risk of urinary tract infections, according to recently published research in Pediatrics.

Coaching adults with chronic kidney disease to increase water intake did not significantly slow the decline in kidney function at 1-year follow-up, according to a randomized clinical trial that will appear in JAMA.

Pre-dialysis and post-dialysis fluid overload were associated with increasing patient age, a lower BMI and multiple comorbidities and strongly predicted all-cause mortality, according to a study published in Nephrology Dialysis Transplantation. The findings question long-held thoughts that higher interdialytic weight gain is worse for outcomes and needs to be expanded.