National Kidney Foundation releases recommendations for use of genetics in nephrology
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Key takeaways:
- Overall, the report offers 56 recommendations to guide genetics in nephrology.
- One topic covered is bias and disparities in genetic testing.
The National Kidney Foundation has released new recommendations for the use of genomics to test for, and diagnose, genetic kidney diseases, according to a press release.
“The integration of genetic testing into nephrology practice marks a transformative shift toward precision medicine,” Joseph Vassalotti, MD, chief medical officer of the NKF, said in the release. “This report provides a clear path forward for nephrologists with algorithms for symptomatic and at-risk individuals, as well as a road map for implementation of genetic testing, ensuring kidney specialists are well-equipped to offer the most accurate diagnoses and personalized treatments for their patients.”
The report is authored by professionals in genetic, nephrology and allied professions, offering practices for incorporating genetic testing in clinical settings to facilitate personalized treatment plans for patients with kidney disease. The group was co-chaired by Ali Gharavi, MD, of Columbia University Irving Medical Center, and Nora Franceschini, MD, MPH, of the University North Carolina, each with experience in nephrology and genetics.
Researchers formed four groups covering various topics to create practical clinical decision-making algorithms. Overall, the group developed 56 recommendations to guide genetics in nephrology. The recommendations address genetic testing for monogenic disorders and identify risk factors for oligogenic and polygenic causes of kidney diseases.
Specifically, the report covers guidance on who should offer genetic testing and the need for pre- and post-test counseling, testing symptomatic and at-risk individuals, APOL1 genetic testing, bias and disparities in genetic testing and additional relevant topics.
Researchers also addressed ethical, legal and social considerations for items such as the Genetic Information Nondiscrimination Act, and informed consent and genetic counseling, according to the release. It also highlighted disparities within genetic testing access.
The manuscript emphasized the importance of specialized training and education, further research and collaboration between health care providers, policymakers and patients.
The guidelines will be published in an upcoming issue of the American Journal of Kidney Diseases.
References:
Franceschini N, et al. Am J Kid Dis. 2024;doi.org/10.1053/j.ajkd.2024.05.010.
National Kidney Foundation Unveils Recommendations for Genetic Testing in Kidney Disease. https://www.kidney.org/news/national-kidney-foundation-unveils-recommendations-genetic-testing-kidney-disease. Published Aug. 8, 2024. Accessed Aug. 12, 2024.
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