Diabetes mellitus may impact CKD-mineral and bone disorder biomarkers in adults on PD
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Key takeaways:
- Patients with diabetes mellitus had higher aortic pulse wave velocity levels vs. patients without diabetes.
- Log-FGF23 was an independent predictor of aortic pulse wave velocity.
Diabetes mellitus may modify the link between chronic kidney disease-mineral and bone disorder biomarkers and aortic stiffness in adults on peritoneal dialysis, according to recently published data.
“The high prevalence of end-stage renal disease and its related cardiovascular burden are major public health concerns worldwide,” Hsiang-Jung Huang, and Bang-Gee Hsu, of the department of Internal Medicine at the Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation in Taiwan, and colleagues wrote. “Aside from the well-established traditional risk factors, chronic kidney disease-mineral and bone disorder (CKD-MBD), a dysregulation of mineral and bone metabolism exacerbated by worsening kidney disease, plays a crucial role in the pathogenesis of CVD.”
In a cross-sectional study of 213 patients, researchers evaluated the association of four CKD-MBD biomarkers: intact parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), soluble klotho and fetuin-A, with aortic stiffness in patients on PD.
Researchers obtained age, gender, PD vintage, dialysis modalities, comorbidities and medications from patient medical records, and used aortic pulse wave velocity (PWV) and enzyme-linked immunosorbent measurements to compare patients. Of the included patients, 81 had diabetes mellitus.
Findings showed patients with diabetes mellitus (DM) had higher aortic PWV levels compared with patients without (9.9 vs. 8.6 m/s, P<.001). FGF23 levels were lower in the DM group (462 vs. 1,237 pg/mL, P=.028). Log-FGF23 was an independent predictor of aortic PWV in patients with DM and had interacted between FGF23 and DM status (P=.016), researchers reported.
“Further studies are needed to clarify the potential mechanisms underlying the effect of FGF23 and DM status interaction on aortic stiffness in patients undergoing PD,” the researchers wrote.
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