High-flux hemodialysis may not increase vitamin B loss
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Key takeaways:
- Median reduction ratio of serum vitamin B1 after a hemodialysis session was 38%.
- Median concentration of serum vitamin B1 in the dialysate was 0.3μg/L.
High-flux hemodialysis may not increase the loss of vitamin B compared with low-flux hemodialysis, and patients may risk vitamin B deficiency regardless of the modality, according to recently published data.
“Patients on hemodialysis (HD) are at risk for vitamin B deficiency for several reasons, including insufficient dietary intake, imposed dietary limitation, improper absorption of vitamins, use of certain medications and vitamin loss during HD treatment,” Yan Wang, lead researcher, of the department of nephrology at Peking University People’s Hospital, and colleagues, wrote in the study.
Researchers aimed to identify the loss of vitamin B1, B3, B5 and B6 in a single HD session, and to evaluate the effect of high-flux hemodialysis (HFHD) on vitamin B removal.
The study enrolled 76 patients on maintenance HD in a single center. Patients were categorized into LFHD and HFHD groups. A blood test measured vitamin B1, B3, B5 and B6 concentrations in the dialysate and blood before and after HD sessions. Multivariable linear regression analyses calculated the association between HFHD and vitamin B loss, and researchers compared the difference between the two groups of patients.
Results showed the median reduction ratios of serum vitamin B1, B3, B5 and B6 after a single HD session were 38.1%, 24.9%, 48.4% and 44.7%, respectively. The median concentration of the same vitamins in the dialysate was 0.3 μg/L, 2.9 μg/mL, 2 μg/L and 0.4 ng/mL, respectively. Researchers observed no difference in either the reduction ratio of vitamin B in blood or the concentration in dialysate between LFHD and HFHD groups.
“Vitamin B1, B3, B5 and B6 can be removed by HD and HFHD does not increase the loss,” Wang and colleagues wrote. “This result suggests that chronic HD patients are prone to have vitamin B deficiencies without supplementation regardless of the modality.”
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