Higher plasma omeintin-1 level correlates with reduced subsequent hospital admission, stay
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Among patients on incident peritoneal dialysis, higher plasma omeintin-1 level quartile correlates with reduced subsequent hospital admissions and shorter hospital stays, according to data published in Kidney Medicine.
Further, higher plasma omentin-1 level quartile does not correlate with patient or technique survival.
“Omentin-1 is an adipokine with anti-inflammatory and cardioprotective properties. The objective of this study was to determine the prognostic role of plasma omentin-1 levels in a cohort of 152 incident ... (PD) patients,” Win Hlaing Than, MBBS, MSc, from the Carol & Richard Yu Peritoneal Dialysis Research Centre and department of medicine and therapeutics at the Prince of Wales Hospital, and colleagues wrote. They added, “In the present study, we examined the prognostic roles of plasma omentin-1 levels and its corresponding mRNA expression in adipose tissue in incident PD patients.”
In a retrospective analysis of a prospective observational study, researchers examined data for 152 patients on incident PD. During mini-laparotomy for catheter insertion, researchers collected 1 gram to 2 grams of subcutaneous and pre-peritoneal adipose tissue samples. The tissue samples from the six patients without kidney disease were used as the healthy control group.
Patients underwent testing at 4 to 6 weeks after becoming stable on PD, and then researchers collected plasma and PD effluent samples for omentin-1 levels measurement.
With patient survival, technique survival, hospital admission and duration of stay serving as primary outcomes, researchers considered plasma omentin-1 levels and adipose tissue omentin-1 mRNA expression as the predictors.
Researchers conducted time-to-event analyses and linear regression analysis for hospitalization.
After a follow-up of up to 5 years, researchers identified no significant relationship between plasma omentin-1 level and its adipose tissue mRNA expression. Although higher plasma omentin-1 level quartile did not correlate with patient survival or technique survival, it was associated with a lower number of hospital admissions (P = .07) and shorter hospital stay (P = .04). An adjusted model using multivariable linear regression analysis revealed consistent results.
“In contrast, adipose tissue omentin-1 mRNA expression level or PD effluent omentin-1 level was not associated with clinical outcomes. Our results suggest that plasma omentin-1 level may be a valuable tool for risk stratification of PD patients,” Than and colleagues wrote. They added, “In conclusion, higher plasma omentin-1 level quartile is not associated with patient or technique survival but is associated with a lower number of subsequent hospital admissions and shorter duration of hospital stay in incident PD patients.”
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