Non-diuretic antihypertensive medications extend fatigue after dialysis
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Findings presented at the Renal Research Institute’s Conference showed an increasing number of non-diuretic antihypertensive medications exacerbated fatigue following hemodialysis sessions, extending its duration by hours.
“The purpose of our study was to look at which demographic and clinical variables correlated with fatigue,” Gwendolyn Derk, PhD, of the department of kinesiology and community health at the College of Medicine at the University of Illinois at Urbana-Champaign, said during her virtual presentation. “Our primary [aim] was looking at post-dialysis fatigue duration and seeing if that was positively correlated with the number of anti-hypertensive medications.”
For the study, researchers included 102 patients undergoing maintenance hemodialysis at one of three privately owned dialysis facilities in Illinois (85% of study population was Black; a total of 50 dialysis sessions were captured per patient). In addition to a medical chart review, all patients completed a survey that assessed fluid and blood pressure management, fatigue following dialysis and time to recover and patient-reported outcomes.
Results showed 76% of patients experienced fatigue after dialysis, which took an average of 7.7 hours to recover.
Researchers observed that for each antihypertensive medication added (scale of zero to five) patients experienced an additional 3.5 hours of fatigue after dialysis.
“Ultimately, fatigue has many important contributing factors,” Derk said. “Our model suggests that an increasing number of non-diuretic antihypertensive medications does exacerbate the duration of a patient’s post-dialysis fatigue. We need to do further investigation on this topic, [because] fatigue is a huge component of the quality of life of our hemodialysis patients.”
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Derk G and Wilund K. Poster #2. Presented at: Renal Research Institute’s Conference (virtual meting); April 6-10, 2021.
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