Delayed kidney graft function after heart-kidney transplant linked with worse outcomes
Click Here to Manage Email Alerts
Patients who had delayed kidney graft function after a simultaneous heart and kidney transplant had worse outcomes than those who did not have delayed kidney graft function, according to published findings.
“Although there are multiple studies of [delayed graft function] DGF and its impact in kidney-only transplant recipients, there are limited data about the risk and outcomes for kidney DGF (K-DGF) in multi-organ transplant recipients,” Sandesh Parajuli, MD, and colleagues wrote.
The retrospective analysis used Organ Procurement and Transplantation Network/United Network for Organ Sharing data of 1,161 patients (mean age, 53.89 years; received pre-transplant dialysis, 40.2%) who had a heart and kidney transplant performed within a 48-hour period between 1998 and 2018. Among patients, 311 (27%) had kidney delayed graft function and 850 did not. Researchers compared outcomes between patients who did and those who did not have kidney delayed graft function after a simultaneous heart and kidney transplant.
Investigators found treatment with dialysis before the transplant “was significantly associated with” developing kidney delayed graft function (OR = 3.95). These patients had a higher risk for mortality (hazard ratio = 1.99;) and death censored kidney graft failure (HR = 3.51) compared with those who did not have kidney delayed graft function, the researchers wrote.
“Similar to kidney-only recipients, [kidney delayed graft function] K-DGF in [simultaneous heart and kidney] SHK recipients is associated with worse outcomes,” researchers wrote. “Careful matching of recipients and donors, as well as peri-operative management, may help reduce the risk of K-DGF and the associated detrimental effects.”
Collapse
Read more about
Click Here to Manage Email Alerts