Frequent exercise may reduce mortality risk in patients on hemodialysis
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Physical activity was associated with a lower risk for mortality in patients on maintenance hemodialysis, according to results presented at the virtual ASN Kidney Week.
Reduced mortality risk included deaths due to cardiovascular disease.
“People receiving maintenance hemodialysis (MHD) are at higher risk of cardiovascular disease (CVD) and death,” Amelie Bernier-Jean, MD, of the University of Sydney, and colleagues wrote in a poster. “Regular exercise training reduces CVD mortality in people with coronary heart disease, but the potential survival benefits for adults undergoing MHD are unproven. We assessed the association between self-reported physical activity (PA) and mortality in a very large cohort of people receiving MHD.”
For the DIET-HD study, Bernier-Jean and colleagues included 6,147 individuals from Europe and South America, and classified participants by self-reported physical activity levels: frequent (exercised twice a week or more) occasional (exercised up to once a week) or sedentary. Overall, 20% of participants reported frequent physical activity, 32% reported occasional physical activity and 48% reported being sedentary.
Patients were followed for a mean of 3.82 years, during which 2,337 deaths occurred (45% from cardiovascular disease causes).
Researchers observed physical activity was associated with a lower risk of all-cause mortality, cardiovascular disease mortality and non-cardiovascular disease mortality.
More specifically, frequent physical activity led to adjusted hazard ratios of 0.82 for all-cause mortality, 0.77 for cardiovascular disease mortality and 0.88 for non-cardiovascular disease mortality.
Based on these findings, Bernier-Jean and colleagues recommend exercise be considered “as part of the clinical management” for these patients.
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Bernier-Jean A, et al. PO1038. Presented at: ASN Kidney Week. Oct. 22-25, 2020 (virtual meeting).
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