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Genetic and environmental influences correlate with metabolic syndrome and CKD
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Investigators found significant correlations between genetic and environmental influences on metabolic syndrome and chronic kidney disease, according to a recently published study.
“In a large Swedish twin population, we aimed to systematically quantify the genetic and environmental influences on the phenotype variation and covariation (correlation) for traits of metabolic syndrome and CKD,” Xu Chen, MD, of the Institute for Maternal Fetal Medicine in China, and colleagues wrote.
Researchers studied 4,721 sets of Swedish twins, with 34% defined as having metabolic syndrome and 20% as having CKD. The genetic and environmental contributions to the correlations between traits of metabolic syndrome and CKD were estimated by using twin-based bivariate structural equation models.
Findings showed 51% of the phenotype correlations between metabolic syndrome and CKD were explained by genes, 15% were explained by shared environment and 34% were explained by nonshared environment. The overall correlation between metabolic syndrome and eGFR defined CKD was 0.16.
“This is the first study to investigate the relative importance of genes and environment on the correlation between metabolic syndrome and CKD,” Chen wrote. “Our results indicate that the observed genetic contribution to the correlation between metabolic syndrome and eGFR-defined CKD in our study is compatible with a direct effect of metabolic syndrome on CKD.”
According to the study, the genetic contribution for the correlation between abdominal obesity and eGFR is relevant as it suggests an important role for abdominal obesity in the link between metabolic syndrome and CKD. – by Erin T. Welsh
Disclosures: The authors report no relevant financial disclosures.
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