Healio
Healio
January 03, 2019
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Lower serum albumin related to higher risk of incident ESRD

Lower serum albumin in community-dwelling U.S. adults was related to a higher risk of ESRD, according to a study published in Nephrology Dialysis Transplantation. These results were revealed to be independent of patient baseline urine albumin-to-creatinine ratio, eGFR and other related risk factors.

“To our knowledge, this is the first study to demonstrate an association between serum albumin concentrations and ESRD while accounting for urine ACR in a community-dwelling adult population,” wrote the authors. “A prior analysis of the Cardiovascular Health Study demonstrated that lower serum albumin was associated with decline in eGFR, rather than ESRD, in a community-based cohort of persons aged 65 years and older.”

A population-based community-living cohort of 19,633 patients from the Reasons for Geographic and Racial Differences in Stroke study was included. Patients were 45 years or older and had baseline serum albumin, creatinine, cystatin C and spot urine ACR measured. Researchers calculated eGFR from the Chronic Kidney Disease Epidemiology Collaboration combined creatinine-cystatin C equation.

Researchers noted that the limitations of the study included a lack of patients who were of other races than black or white and that relative impression of serum albumin measurements may have underestimated its relationship with incident ESRD.

“In conclusion, we show that lower serum albumin, an inexpensive and widely available biomarker, is associated with incident ESRD in community-dwelling adults. This association is independent of CKD risk factors, baseline eGFR and urine ACR,” wrote the authors. - by Scott Buzby

Disclosure: Walther reports no relevant financial disclosures.

Sources/Disclosures

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Source:

Walther CP, et al. Nephrol Dial Transplant. 2018;doi:10.1093/ndt/gfx331.