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Low education level associated with increased risk of CKD in Dutch population
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Low socioeconomic status when related to education level correlated with an increased risk of chronic kidney disease in the Dutch general population, according to recently published results.
Researchers assessed data on 6,078 participants from the community-based Prevention of Renal and Vascular End-stage Disease Study. Investigators classified education level as low, medium or high. The eGFR was used to assess kidney function by serum creatinine and cystatin C at five examinations during 11 years of follow-up. In participants who did not have CKD at baseline, investigators defined incident CKD as a new-onset eGFR of less than 60 mL/min/1.73 m2 and/or urinary albumin of 30 mg/24 hour or greater. Cox regression and linear mixed models were used to estimate the main effects.
Results showed 861 participants with incident CKD. Investigators noted lower education correlated with higher rates of incident CKD and accelerated decline in eGFR. The relationship between education and incident CKD was mediated by factors that included smoking, potassium excretion, BMI, waist-to-hip ratio and hypertension. An analysis of the annual eGFR exchange demonstrated the correlation between education and incident CKD was mediated by magnesium excretion, protein intake and diabetes. – by Monica Jaramillo
Disclosure: The study was funded by the Dutch Kidney Foundation (grant E.033).
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