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Kidney function recovery in patients with AKI requiring dialysis may benefit from fewer hemodialysis sessions

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Melissa Jordan

SAN DIEGO — For patients with acute kidney injury-requiring dialysis who were transferred to a rehabilitation center, approximately 69% recovered and no longer required hemodialysis, according to data presented at ASN Kidney Week 2018.

“The presence of anemia or the absence of anemia is associated with renal recovery vs. no renal recovery, and the number of hemodialysis sessions and the number of intradialytic hypotension episodes are also associated with no renal recovery,” Melissa Jordan, MD, said here.

Jordan and colleagues conducted a single-center retrospective cohort study of 42 patients who were discharged from the University of Kentucky hospital with AKI-requiring dialysis (AKI-D) and were admitted to an acute care rehabilitation center with ongoing need for hemodialysis.

Investigators found 17% of patients died after discharge and 12% died during their stay, according to the study. Of the 19% of patients who were hemodialysis-dependent at time of discharge, 38% died and one patient recovered kidney function.

The researchers wrote that the total number of hospital dialysis days was independently

associated with kidney recovery at discharge and the number of intradialytic hypotension events during the stay was associated with death or hemodialysis-dependent status at follow-up.

Jordan noted several questions to be addressed in further studies.

“Are we able to back-off hemodialysis sessions? Can we change patients’ prescriptions to try to reduce intradialytic hypotensive episodes? I think we have found some parameters that can at least re-stratify patients, but I think further ongoing and larger studies would be very beneficial to help patients who are now being discharged with AKI-D and followed-up in dialysis centers.” – by Kristine Houck, MA, ELS, and Joe Gramigna

Reference:

McAdams M, et al. Abstract SA-PO537. Presented at: ASN Kidney Week; Oct. 23-28, 2018; San Diego.

Disclosure: Jordan reports no relevant financial disclosures.