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Medication adherence linked with psychological morbidity in patients with kidney failure
In young adults with kidney failure, wellbeing and medication adherence correlated with psychological morbidity, according to a published study.
"In young adults receiving kidney replacement therapy, wellbeing and medication adherence were both associated with psychologic[al] morbidity,” Alexander J. Hamilton, MD, told Healio.com/Nephrology. “Compared to kidney transplantation, dialysis treatment is associated with poorer wellbeing and medication adherence.”
Hamilton and colleagues performed a cross-sectional online survey of young adults on kidney replacement therapy for kidney failure. Investigators recruited 976 young adults, of which 64% responded to the survey. There were 417 young adults with transplants and 173 young adults on dialysis. The United Kingdom Renal Registry was used to obtain additional clinical information. Age- and sex-adjusted regression models were used to compare outcomes by treatment modality, after survey weights to account for response bias by gender, ethnicity and socioeconomic status were applied. Multivariable linear regression was used to evaluate psychosocial associations with scores on Warwick-Edinburgh Mental Wellbeing Scale and the eight-item Morisky Medication Adherence Scale.
Results showed a positive association between wellbeing and extraversion, openness, independence and social support. However, wellbeing was negatively associated with neuroticism, negative body image, stigma, psychological morbidity and dialysis. Investigators noted a correlation between greater medication adherence and living with parents, conscientiousness, physician assessed satisfaction, patient activation, age, male sex and lower adherence with comorbidity, dialysis, education, ethnicity and psychological morbidity. – by Monica Jaramillo
Disclosure: Hamilton reports he receives funding on a Tony Wing clinical studentship from Kidney Care UK and Kidney Research UK.
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Hamilton AJ, et al. Clin J Am Soc Nephrol.2018;doi:10.2215/CJN.02450218.