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Intervention with vitamin D in patients with CKD may improve endothelial function
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Results from a recently published study demonstrated short-term intervention with vitamin D correlated with an improvement in endothelial function as measured by flow-mediated vasodilation. According to the authors, the findings show vitamin D positively impacts vascular disease in patients with chronic kidney disease.
“[Vitamin D] treatment affects vascular function in terms of ameliorated endothelial function in patients with chronic kidney disease,” study co-author Kristina Lundwall, MD, told Healio.com/Nephrology. “Most pronounced effects are seen in younger patients, probably due to an earlier stage in their vascular disease, with less structural vascular changes.”
Researchers systematically searched PubMed, Medline, Web of Science, EMBASE and Cochrane trials and reviews to identify randomized controlled trials on the use of any vitamin D compound at any stage of CKD with flow-mediated vasodilation as an outcome. They found four trials with a total of 305 patients. Investigators performed fixed- and random-effects models with the use of standardized mean different effect size after treatment for each trial.
One trial investigated 1 g and 2 g of paricalcitol as two treatments, so researchers split the results for analysis. The mean age ranged from 44 to 65 years in all trials. Investigators noted all patients had stage 3 to 4 CKD. One study used cholecalciferol as treatment and the others examined paricalcitol. The studies lasted from 12 to 16 weeks. In a fixed model, researchers found an association between intervention with vitamin D and ameliorated flow-mediated vasodilation. According to researchers, heterogeneity was substantial and significant results were seen with secondary analysis using random model analysis. – by Monica Jaramillo
Disclosures: Lundwall reports no relevant financial disclosures. Please see the full study for a list of all other authors’ relevant financial disclosures.
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