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Underlying disease, age cited as factors linked with recovery of kidney function in children with presumed ESKD
Results indicated recovery of kidney function in pediatric patients with presumed ESKD on maintenance dialysis 2 years after initiation was rare and correlated with underlying kidney disease and age.
Researchers collected data from the European Society for Pediatric Nephrology/European Renal Association-European Dialysis and Transplant Association Registry for 6,574 patients with ESKD who began dialysis when they were younger than 15 years old. Investigators defined kidney function recovery as discontinuation of dialysis for a minimum of 30 days. A cumulative incidence completing risk approach and adjusted Cox proportional hazard models were used to determine time to recovery.
Two years after the start of dialysis, investigators found 130 patients recovered kidney function after a median of 5 months on dialysis. Recovery occurred more often in patients with vasculitis, ischemic kidney failure and hemolytic uremic syndrome compared with patients with congenital anomalies of the kidney and urinary tract. Other factors correlated with recovery included younger age and initiation on hemodialysis rather than PD. Recovery was temporary for 42 patients who returned to kidney replacement therapy after a median 19.7-month recovery period. – by Monica Jaramillo
Disclosure s : The authors report no relevant financial disclosures.
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Bonthuis M, et al. Clin J Am Soc Nephrol.2018;doi:10.2215/CJN.01500218.