Healio
Healio
September 19, 2018
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Bilateral oophorectomy may increase the risk of CKD in premenopausal women

Recently published results showed a higher risk of developing chronic kidney disease among premenopausal women, particularly those aged 45 years or younger, who undergo bilateral oophorectomy.

Andrea Kattah
Andrea G. Kattah

Andrea G. Kattah , MD, and colleagues age matched 1,653 women residing in Olmsted County, Minnesota who underwent bilateral oophorectomy before the age of 50 years and before the onset of menopause to a group of 1,653 women who did not undergo oophorectomy between 1988 and 2007. Researchers assessed the incidence of CKD, primarily defined using eGFR, for a median of 14 years.

Results showed a 6.6% higher risk of developing CKD among women who underwent bilateral oophorectomy compared to those who did not undergo the procedure. Women younger than 46 years old had a higher risk of kidney failure, researchers found, with a 7.5% increased risk of CKD.

“For the first time, we have shown an important link between estrogen deprivation in younger women and future kidney damage. Women who undergo bilateral oophorectomy have an increased long-term risk of chronic kidney disease,” Kattah told Healio.com/Nephrology. “Women considering bilateral oophorectomy for the prevention of ovarian and breast cancer should be counseled about the increased risk of morbidity and mortality, which includes an increased risk of chronic kidney disease.” – by Casey Tingle

 

Disclosure: Kattah reports no relevant financial disclosures.

Sources/Disclosures

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Source:

Kattah AG, et al. Clin J Am Soc Nephrol. 2018;doi:10.2215/CJN.03990318.