This article is more than 5 years old. Information may no longer be current.
Mortality risks similar for patients with CKD in China, US but prevalence is lower
Click Here to Manage Email Alerts
A joint research study by clinicians in China and in the United States on the rate of mortality among patients with chronic kidney disease showed that, while individuals shared similar risk factors for kidney disease, the prevalence and extent of those risk factors vary between the two countries.
Completed and funded by the Peking University Health Science Center Joint Institute for Translational and Clinical Research and the University of Michigan Health System, the researchers, directed by lead author and Peking University nephrologist Jinwel Wang, MD, “hypothesized that, given the difference between China and the U.S. in terms of ongoing ‘epidemiologic transitions’ in the former and previously reported differences with respect to prevalence of [chronic kidney disease] CKD by stage, that the relationship between mortality and CKD may be different between the two countries. Therefore, we sought to investigate the relationship between reduced eGFR and increased albumin to creatinine ratio (ACR) with the risk of mortality using nationally representative population-based samples from China and the U.S.”
Nationally representative data on the mortality of adult dialysis populations (20 years old or older) were taken from NHANES (2005 to 2010, n=15,209) in the United States and the China National Survey of Chronic Kidney Disease (n=25,269). CKD was defined in the data review as an eGFR of less than 60 ml/min/1.73 m2 or albuminuria (defined as ACR ≥30 mg/g).
After the medical record review, the Chinese sample showed a lower proportion of patients with an eGFR of less than 60 ml/min/1.73 m2 (3.7% vs. 6.9%) and albuminuria (7.6% vs. 9%) compared to the U.S. sample.
“Although the two CKD indicators showed more obvious risk for mortality in the U.S. than in urban China, no significant interaction by country was found,” the authors concluded. “We believe that while opportunities for prevention of kidney disease are significant in both countries, the higher prevalence of earlier stages of the disease in [the U.S.] should serve as an imperative for aggressive primary and secondary preventive efforts to preempt the devastating and costly downstream consequences of CKD.”
Disclosures: This work was supported by the University of Michigan Health System – Peking University Health Science Center Joint Institute for Translational and Clinical Research (BMU20140479) and by Peking University First Hospital Research Grant for Returned Scholars (2016GG01). The authors reported no relevant financial disclosures.
Click Here to Manage Email Alerts