This article is more than 5 years old. Information may no longer be current.
Study finds high prevalence of hypertension in children with autosomal dominant polycystic kidney disease
According to data published in the Clinical Journal of the American Society of Nephrology, researchers found a high prevalence of hypertension in children with autosomal dominant polycystic kidney disease.
Investigators conducted the retrospective multicenter study to collect ambulatory blood pressure monitoring, the preferred method to diagnose hypertension in pediatrics, recordings from patients younger than 18 years of age with autosomal dominant polycystic kidney disease (ADPKD). Investigators collected data on 310 children with ADPKD from 22 European centers. They found 95% of children had normal kidney function at the time when ambulatory blood pressure monitoring was performed and reference data for ambulatory blood pressure monitoring were available for 292 patients. Rates of children with hypertension and/or those treated with antihypertensive drugs were 31%, 42% and 35% during daytime, night-time or the entire 24-hour cycle, respectively. The study also confirmed a strong association between blood pressure values and kidney enlargement among pediatric patients with ADPKD.
Disclosure s : Schaefer received honoraria for consulting services from Otsuka Pharmaceutical and Emma serves on the Otsuka Pharmaceutical safety board.