This article is more than 5 years old. Information may no longer be current.
VIDEO: Consider changing pharmacokinetics in the drug dosing of patients with acute kidney injury
Click Here to Manage Email Alerts
AUSTIN, Texas — At the National Kidney Foundation Spring Clinical Meetings, Mary Vilay, PharmD, spoke about drug dosing across the spectrum of acute kidney injury.
“This is a challenging area given the fact that in the study of acute kidney injury, it is hard to decide what the patient’s renal function truly is. In that particular setting, you may want to consider that if the patient has established acute kidney injury, the fact that they have decreased urine output and the serum creatine is rising, that you essentially are dosing a patient for creatine clearance or [glomerular filtration rate] GFR for less than 10 [mL] to 15 mL per minute,” Vilay said.
She also said to consult drug dosing references as an initial guide, but one needs also to consider how the pharmacokinetics of the drug have potentially changed, as well as the overall goals of therapy.