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Study shows kidneys from older donors should not be excluded
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Age cut-offs for deceased organ donors prevent quality kidneys from being available to patients, according to a study published in the Clinical Journal of the American Society of Nephrology Even kidneys from donors older than 80 years of age can function for years after transplantation, the study found.
Luigi Biancone, MD, from University of Torino, in Italy, and his colleagues analyzed information on deceased donor kidney transplants performed at the Turin University Renal Transplant Center from 2003 through 2013. The researchers identified a total of 647 transplants from “extended criteria” donors, which were defined as all donors >60 years and those aged 50 to 59 years with certain risk factors.
After a median follow-up of 4.9 years, patient and kidney survival were comparable among age groups (50-59 years, 60-69 years, 70-79 years, and ≥80 years). The 5-year patient survival rates ranged from 87.8% to 90.1%, and the 5-year kidney survival rates ranged from 65.9% to 75.2%.
Rates of kidney discard before transplantation were similar for kidneys from donors aged 50 to 79 years, but the discard rate was strikingly higher among kidneys from octogenarian donors.
“The results of this study support the use of extended criteria donors, even donors older than 80 years, but they have to be accurately selected and managed with dedicated protocols,” said Biancone.
The article, entitled “Long-term Outcomes and Discard Rate of Kidneys by Decade of Extended Criteria Donor Age,” appears online at http://cjasn.asnjournals.org/