Study shows HPV vaccine effective in adolescents with kidney disease

Human papillomavirus (HPV) vaccination stimulates robust and sustained immune responses in girls and young women with chronic kidney disease and those on dialysis, but less optimal responses to the vaccine were observed among those with a kidney transplant. The findings, which appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN), suggest that HPV vaccination provides considerable benefits for kidney disease and dialysis patients but may not be as beneficial for kidney transplant recipients.

Girls and young women with CKD, as well as those who have developed kidney failure, have compromised immune systems, and as a result they have a significantly elevated risk of developing cervical cancer and genital warts if they become infected with HPV. Therefore, the potential health benefits of HPV vaccination may be substantial in this vulnerable population.

To examine the immune response to HPV vaccination among these girls and young women, a team led by Delphine Nelson, MD, MHS and Jeffrey Fadrowski, MD, MHS, from Johns Hopkins University School of Medicine, conducted a study that included 57 female patients aged 9 to 21 years, of whom 25 had CKD, 9 were on dialysis, and 23 had received a kidney transplant. Participants received the standard 3-dose vaccine series of the HPV vaccine, and immune responses were determined by measuring the amount of antibody made by the patients against each of the 4 HPV genotypes included in the vaccine. Antibody levels were measured prior to vaccine dose 1, less than 12 months after vaccine dose 3, and 12 months or longer after vaccine dose 3.

The investigators found that study participants with CKD and those on dialysis had antibody levels above the threshold that indicates protection from infection, but a significant proportion of patients with kidney transplants showed evidence of an inadequate antibody response.

“This is important information as it means that patients with a kidney transplant, whom we know are at increased risk of developing cervical cancer from HPV infection, may not be protected from HPV infections from the HPV genotypes included in the vaccine,” said Dr. Nelson. “The next step is to determine the best way to protect these young women. Some potential interventions include a higher dose of the vaccine, or an additional booster.” She noted that future studies are needed to test these and other strategies.

Disclosures: The study was funded by Merck & Co’s Investigator-Initiated Studies Program. Merck & Co manufactures Gardasil, the HPV vaccine used in this study. Merck & Co also analyzed the antibody levels to the HPV genotypes.