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Hepatitis C News
Pilot study finds HCV treatment safe in pregnancy
SEATTLE — A small pilot study of hepatitis C treatment in pregnant women found that their response to ledipasvir-sofosbuvir therapy is similar to the viral response observed in nonpregnant individuals and identified no safety concerns associated with treatment, according to findings presented at CROI.
HCV reinfection remains high in MSM with HIV regardless of treatment
Long-term surveillance among men who have sex with men with HIV after clearance of hepatitis C may be warranted as reinfection rates remain high and continue to occur more than 11 years after clearance regardless of treatment, according to a study presented at CROI.
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Acute HCV decreasing in men who have sex with men with HIV
The rates of hepatitis C incidence among men who have sex with men with HIV has significantly decreased in London since the epidemic peak in 2015, coinciding with wider access to direct-acting antiviral therapy, according to data presented at CROI.
IV drug use, HCV predict syphilis in women with HIV
SEATTLE — A recent analysis found that IV drug use and hepatitis C virus infection were the best predictors of incident syphilis among women with HIV.
High cure rates follow HCV positive-to-negative heart transplants
Hepatitis C virus-negative candidates who receive transplants with HCV-infected hearts experience acceptable outcomes and high cure rates, according to recently published study findings.
Hooked on ID with Anthony P. Cannella, MD, MSc, FACP
As a fourth-year medical student at the University of South Florida College of Medicine, I did an elective rotation with Dr. John Greene at Moffitt Cancer Center. I was awestruck as I saw the fellows and Dr. Greene make incredible diagnoses based on details from the patients’ histories. We conversed with radiologists, pathologists, other internal medicine subspecialists and surgeons; a constant busy mission to determine what kind of infections patients had. Their knowledge was superior, having to understand different cultures, practices and hobbies that could lead to the diagnosis. I witnessed the way that the infectious disease physicians conversed with others; their pleasant demeanor toward patients and staff was infectious. Most compelling of all was the microbiology lab, where you came face to face with your patients’ foes: Staphylococcus, Acinetobacter, Fusarium, Cryptosporidium, etc. This to me was the defining moment: looking into the viewing ocular pieces of the microscope to view something that was a millionth our size and had the potential to cause incredible pathologic havoc. This experience, which I also had during my internal medicine residency, is what led me to my interest in host-pathogen responses and to choose a career in infectious diseases.
Higher limit of detection identifies 97% of HCV viremic infections
Researchers determined a target limit of detection for hepatitis C point-of-care tests that would identify 97% of viremic infections among all populations including low- and middle-income countries, according to a recently published study.
Among injection drug users, HIV more prevalent in women than men
Study findings showed a higher prevalence of HIV among women who inject drugs compared with men, and researchers recommended developing gender-sensitive harm reduction services.
Traditional risk factors ‘contribute greatly’ to disease in adults with HIV
Study findings showed that traditional risk factors such as smoking, high cholesterol, hypertension and chronic hepatitis C virus infection “contribute greatly” to disease in adults living with HIV, and eliminating them is “essential” to the health of these patients, researchers reported in The Lancet HIV.
DAA therapy regardless of SVR reduces hepatic, extrahepatic mortality
Results of a prospective study showed that treatment with direct-acting antivirals for hepatitis C correlated with significantly reduced risks for hepatocellular carcinoma and mortality, according to a study published in The Lancet.
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